1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-
WUN29654
CAS: 2407829-65-4
Molecular Formula: C17H12N2O5
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- - Names and Identifiers
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- - Physico-chemical Properties
| Molecular Formula | C17H12N2O5 |
| Molar Mass | 324.29 |
| Solubility | Soluble in DMSO |
| Storage Condition | -20℃ |
| Use | WUN29654 is a CRBN modulator, which showed CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 vale of ~21.53μM. WUN29654 was reported in patent WO 2020006262 (compound II). WUN29654 has CAS#2407829-65-4, no formal name For the convenience of scientific communication, we named it as WUN29654 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature。 |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- - Reference
| Reference Show more | Gray, Nathanael; Zhang, Tinghu; Fischer, Eric; Verano, Alyssa; He, Zhixiang; Du, Guangyan; Donovan, Katherine; Nowak, Radoslaw; Yuan, Christine. 2-(2,6-Dioxopiperidin-3-yl)benzo[de]isoquinoline-1,3(2H)-diones as CRBN modulators and their preparation. PCT Int. Appl. (2020), WO 2020006262. |
1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.084 ml | 15.418 ml | 30.836 ml |
| 5 mM | 0.617 ml | 3.084 ml | 6.167 ml |
| 10 mM | 0.308 ml | 1.542 ml | 3.084 ml |
| 5 mM | 0.062 ml | 0.308 ml | 0.617 ml |
Last Update：2024-01-02 23:10:35
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